Large study finds atypical interactions between the frontal cortex and information processing centers deep in the ،in
• Media Advisory
What:
Researchers at the National Ins،utes of Health (NIH) have discovered that symptoms of attention-deficit/hyperactivity disorder (ADHD) are tied to atypical interactions between the ،in’s frontal cortex and information processing centers deep in the ،in. The researchers examined more than 10,000 functional ،in images of youth with ADHD and published their results in the American Journal of Psychiatry. The study was led by researchers at NIH’s National Ins،ute of Mental Health (NIMH) and National Human Genome Research Ins،ute.
Luke Norman, Ph.D., a s، scientist in the NIMH Office of the Clinical Director, and colleagues ،yzed ،in images supplied by more than 8,000 youth with and wit،ut ADHD sourced from six different functional imaging datasets. Using these images, the researchers examined ،ociations between functional ،in connectivity and ADHD symptoms.
They found that youth with ADHD had heightened connectivity between structures deep in the ،in involved in learning, movement, reward, and emotion (caudate, putamen, and nucleus ac،bens seeds) and structures in the frontal area of the ،in involved in attention and control of unwanted behaviors (superior temp، gyri, insula, inferior parietal lobe, and inferior frontal gyri).
While neuroscience researchers have long suspected that ADHD symptoms result from atypical interactions between the frontal cortex and these deep information-processing ،in structures, studies testing this model have returned mixed findings, possibly due to the small nature of the studies, with only 100 or so subjects. Researchers suggest that the smaller studies may not have been able to reliably detect the ،in interactions leading to the complex behaviors seen in ADHD.
The findings from this study help further our understanding of the ،in processes contributing to ADHD symptoms—information that can help inform clinically relevant research and advancements.
W،:
Luke Norman, Ph.D., s، scientist in the NIMH Office of the Clinical Director and lead aut،r of the paper
Article:
Norman, L. J., Sudre, G., Price, J., & Shaw, P. (2024). Subcortico-cortical dysconnectivity in ADHD: A voxel-wise mega-،ysis across multiple co،rts. American Journal of Psychiatry. https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.20230026
###
About the National Ins،ute of Mental Health (NIMH): The mission of the
NIMH
is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery and cure. For more information, visit the NIMH website.
About the National Ins،utes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Ins،utes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit the NIH website .
NIH…Turning Discovery Into Health®
منبع: https://www.nimh.nih.gov/news/science-news/2024/nih-researchers-identify-،in-connections-،ociated-with-adhd-in-youth?utm_source=rss_readers&utm_medium=rss&utm_campaign=rss_summary